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A modern alternative is LC-MS/MS on cerebral homogenate at different time-points post-administration

The generalizability is low, given the availability of on-demand beds specifically for the purpose of rapid methadone titrations are rare and highly experienced inpatient addiction medicine clinicians are not available routinely in acute care hospital

International orders may face delays, import duties, or seizure risks depending on origin country and declaration accuracy

The nozzle of the spray bottle should always be kept sterilized and sanitary at all times to prevent any degradation or bacterial contamination of the product

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Therefore, it is crucial for healthcare providers to conduct a thorough evaluation, including a detailed medical history and physical examination, to guide appropriate management