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There were only four downregulated genes in the MYO-2, and three of those DEGs are closely related to the cellular bioenergetics and stress defense: Prdx1 (peroxiredoxin-1) and Txnrd1 (thioredoxin reductase 1) are the members of antioxidant system and have reductase activity on ROS 47,48

Only studies published in English were considered

Schapira AH, Olanow CW (2004) Neuroprotection in Parkinson disease: mysteries, myths, and misconceptions

Dosing can be tricky, too

Side effects Topiramate can cause stomach pain, nausea, diarrhea, anorexia, and problems with taste

In UGT74F1, glucose is transferred to the hydroxyl of SA, creating a glucoside