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Asian J Pharm Clin Res

These measurements allow the calculation of the ratio of GSH/GSSG, or the ratio of reduced to oxidized glutathione, in order to determine the oxidative stress present in cultured mammalian cells in response to a compound

Brahmachari et al., 2010)

Conversely, an adequate supply of BH4 can restore eNOS functionality, enhance NO production and inhibit ROS generation, thus alleviating inflammation and senescence in endothelial cells (34)