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Enzymes converting p-coumaric acid to p-coumaroyl CoA (4CL) and those involved in lignin biosynthesis (COMT, CCR, CAD, Prx) were more active in LY46, consistent with increased levels of lignin intermediates like coniferyl and sinapyl alcohols

In previous study, L-theanine and its derivatives, ethyl 6-bromocoumarin-3-carboxylyl L-theanine (TBrC), could effectively prevent the growth and migration of highly metastatic human cervical cancer cells, which was confirmed by in vitro and in vivo studies (69)

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EGCG is metabolized on one hand through methylation by the catechol- O -methyltransferase (COMT) producing predominantly the primary metabolite di-methoxyl-EGCG (di-OMe-EGCG) [49]

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