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10.1371/journal.pone.0113662 PLoS One 151 TobeE

Aspirin has also been adequately studied in the chemoprevention of colon cancer

The problem arises when this antioxidant defense is overwhelmed or depleted: *Excess HO damages thyroid follicular cells, triggering inflammation and immune activation *Oxidized thyroid proteins become neoantigens - foreign-looking molecules that the immune system attacks, initiating or amplifying autoimmune thyroid disease *Lipid peroxidation in thyroid cell membranes disrupts hormone synthesis and cellular integrity *Chronic oxidative stress accelerates thyroid cell apoptosis and fibrosis - the hallmarks of Hashimoto's progression A landmark review published in Antioxidants (MDPI, 2021) - "The Influence of Oxidative Stress on Thyroid Diseases" - confirmed that decreased glutathione levels appear to be a distinctive parameter related to the activation and development of oxidative stress in Hashimoto's thyroiditis, and that antioxidant interventions represent a promising therapeutic avenue for autoimmune thyroid conditions

(2005) Characterization and expression analysis of a serine acetyltrans- ferase gene family involved in a key step of the sulfur assimila- tion pathway in Arabidopsis.Plant Physiology 137, 220230

Thirty-four percent saw no difference, while only 3.5 percent felt worse