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It is worth noting that, nuclear GSTP inhibited the association between HMGB1 and cPKC and reduced cPKC-mediated HMGB1 phosphorylation through interacting with HMGB1 in response to LPS stimulation

Chen J, Zhao R, Wang Y, Xiao H, Lin W, Diao M et al (2024) G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis

For example, TGF-s, bone morphometric proteins (BMPs) and their related peptides, such as P24 and P20, mediate the differentiation of osteoblasts and chondrocyte lineages via both Smad-dependent and Smad-independent signaling pathways, but they recruit distinct receptor heterotetramers and R-Smad complexes, thus exerting different biological effects on osteogenesis, osteoclastogenesis, and chondrogenesis [167]

Pivac et al., 2023)

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