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Histone Kla is significantly increased on the promoters of M2-like genes in the later stage of stimulated M1 macrophage polarization, suggesting that histone Kla probably acts as a lactate clock to promote the switch from an inflammatory phenotype to a steady-state phenotype in macrophages

A primary concern is the scarcity of comprehensive in vivo studies and clinical trials

10.3168/jds.S0022-0302(89)79318-8

However, a potential drawback is that KD is typically low in dietary Trp [178], the precursor of several neuroprotective AhR ligands and serotonin pathway metabolites

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In vivo antitumor assay All animal operations followed the guidelines of the Institutional Animal Care and Use Committee (IACUC) of the Animal Experiment Center of the Chinese University of Hong Kong (Shenzhen, China, protocol number, CUHKSZ-AE2022004)