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Garcia-Martinez, L., Zhang, Y., Nakata, Y., Chan, H

La poliposis acostumbra manifestarse a partir de los 50 aos con diarrea, dolor abdominal, prdida de peso y mala absorcin grave secundaria a una enteropata con prdida de protenas

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2 Dysregulation of gut microbiota in patients with immune thrombocytopenia The organ with the largest distribution of microorganisms in the human body is the intestine, and the composition of the intestinal microbiota is complex and diverse, including bacteria, fungi, viruses, and protozoa, among which bacteria dominate, with a mass of about 0.2 kg (Sender et al., 2016

The predicted human PK parameters were used to define the escalation steps in this study, while information from nonclinical toxicology studies was used to define the starting dose, following the recommendations of the ICH-S9 Guidance Document