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Japans PMDA and Indias 2019 guidelines lack nanomaterial-specific thresholds, and regulatory divergence often classifies similar products as drugs or devices, impeding harmonized safety standards [297, 298]

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Dexrazoxane is a cyclic derivative of EDTA that easily penetrates the cell membrane and forms a ring-opening iron chelator

It takes approximately 4 to 5 weeks for the drug to reach a steady level in the body, and total effects may not be apparent for at least two months after treatment begins

The authors speculated that variations in participant characteristics, such as age or gender, might account for discrepancies between their findings and those of previous studies