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Ischemic models can be generated in both small and large animals

PMID: 27323014

Injection Site Reactions Intramuscular or IV injections can cause pain, swelling, or redness at the injection site

Why Muscle Twitching or Spasticity Occurs in Stroke Survivors Muscle twitching happens when some muscle fibers get the wrong nerve message and tighten instead of staying relaxed

Chem Biol Interact 159(1):1846

As an extension of the above, the brains high metabolic rate and oxygen consumption make it vulnerable to oxidative stress, which can lead to aging and neurodegenerative diseases like Alzheimers and Parkinsons Disease