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Sellner, J

Increased BDI-II scores resulted from items related to mental and physical fatigue (tiredness/fatigue, loss of energy, items referring to cognitive symptoms such as concentration difficulties) apart from one patient, who had a higher score across most items, while still not meeting the criteria for depression

doi: 10.1111/1751-7915.13479 5 LevyMKolodziejczykAAThaissCAElinavE

This discrepancy primarily stems from methodological variations in patient selection, intervention design, and endpoint assessment, rather than contradicting the established biological plausibility of LC's mechanisms

GIP receptor activation appears to amplify the metabolic benefits beyond what GLP-1 agonism alone can achieve, which is why tirzepatide consistently outperforms semaglutide in head-to-head comparisons

But sometimes, a more-detailed echocardiogram is needed to get a closer look at the mitral valve