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2.6.3 Association mechanism between NADPH metabolic imbalance and ferroptosis Nicotinamide adenine dinucleotide phosphate (NADPH), is closely associated with the pathogenesis and progression of various metabolic diseases, and plays a pivotal role in ferroptosis regulation by modulating antioxidant system function and iron metabolism homeostasis, with its intracellular levels directly dictating cellular susceptibility to ferroptosis (145, 146)

Glutathione c tc dng c ch sn sinh hc t Melatonine nguyn nhn gy en, sm da, tng cng sn xut Pheomelanine gip da trng sng, h tr qu trnh o thi c t ra khi c th

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The inadequate response of the main cytoplasmic antioxidant systems and the enzymes participating in glutathione maintenance may contribute to the vulnerability of hypertensive patients to oxidative stress

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Griffith OW: Biologic and pharmacologic regulation of mammalian glutathione synthesis