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Aggregation of these proteins and the subsequent reduction of FeS clusters, which are essential cofactors for various cellular processes, including electron transport and enzymatic reactions [102], promote proteotoxic stress and ultimately lead to cell death ( Fig

Mechanistically, these therapeutic effects were dependent on the STING signaling pathway, because PEI-PDA@C-176 NPs only slightly reduced the clinical score in CIA-modeled Sting1 +/ mice without improvements in synovitis (54)

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More, PhD Professor, Center for Drug Design expand_more library_books References (1) Swati S