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Preliminary results indicated that both the OLZ+VPA combination regimen and the QUE+VPA combination regimen demonstrated positive signals, as evidenced by the ROR (QUE+VPA:ROR = 1.35

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( i ) Quantification of H2AX foci in cells expressing empty vector or CCNE1 transduced with shRNAs targeting TMLHE alone (shTMLHE) or supplemented with propionylcarnitine or butyrylcarnitine (n = 3 technical replicates representative from 2 independent experiments in each cell line)

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Common Side Effects (affecting less than 5% of patients): Mild injection site irritation or bruising Temporary headache (usually related to detox reactions) Mild nausea or stomach discomfort Brief dizziness or lightheadedness Rare but Serious Reactions : Allergic reactions (rash, difficulty breathing, swelling) Significant blood pressure changes Severe abdominal cramping Drug Interactions : Glutathione can potentially interact with certain chemotherapy drugs and may affect blood clotting in patients taking anticoagulants

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