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The results demonstrated that the silencing of HIF2 or MCJ mitigated the tube formation induced by the conditioned medium from ccRCC cells, and this effect could be rescued by the overexpression of MCJ (Fig

Interventions to modulate NAD + levels Several strategies have been developed to modulate NAD + metabolism, both for mechanistic investigation purposes and to assess their potential therapeutic effects to improve health in aging or disease

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et al.) 149161 (1977)

FSP1 GFP-P2A-BFP cells exhibited similar resistance to RSL3 as WT control cells and both showed sensitization to RSL3-induced ferroptosis following treatment with the FSP1 inhibitor FSEN1 (Fig