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FIGURE 1 2 Retrieval methods The literature review was conducted using several databases, including Web of Science ( ScienceDirect (www.sciencedirect.com), and PubMed ( The search keywords included pomegranate peel extract, Punica granatum L., bioactivity, hydrogels, nanodrugs, tissue engineering, biomedical materials, and their combinations

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Alterations in major signaling pathways TGF signaling In general, tumors co-opt TGF signaling to induce metastasis and chemoresistance through promoting angiogenesis, EMT, increased GSH production, a stem cell phenotype, ECM remodeling, and immune escape [90]

Once reconstituted with bacteriostatic water, store refrigerated and use within 2 to 4 weeks

All other variants (BF_V1, BF_V2, and BF_V3) demonstrated a significant reduction in 3-SH, underlining the dominant effect of oak chips, with only marginal contributions from GSH-IDY or oxygen