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When the gut lining is compromised, inflammatory molecules and toxins can 'leak' into the bloodstream, triggering a systemic inflammatory response that shows up on your face

However, fibroblasts and myofibroblasts will also migrate to an area in the tissue with chronic inflammation and secrete abundant amounts of collagen

Curr Opin Psychiatry 2014;27:327

The initiating factor of ALS is hypothesized to be a combination of multigenic and environmental factors [7] acting as multiple hits toward a threshold at which genetic and epigenetic changes converge into a pathologic cycle of degeneration