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Brazier-Hicks et al., Other groups of GSTs have various roles, e.g., participating in hormone signaling or exhibiting peroxidase and isomerase activity (Gall et al., At the same time, the complex regulation of GST activity is dependent on the transcriptional and post-translational regulation, which is orchestrated by several promoter elements and transcription factors, and by phosphorylation and S-glutathionylation, which may be dependent on light (Dixon and Edwards, Roles of the Multifaceted Glutathione Glutathione, the GST co-substrate is synthesized by two ATP-dependent enzymatic steps in the cytosol and chloroplasts (Diaz-Vivancos et al., 2011)

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