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The lack of upregulation of SLC22A5 at the gene level in CAR suggests that existing transporter capacities in bovine PBMC were adequate to handle the higher substrate flux from the extracellular to the intracellular space

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(PubMed) Lodi R, Hart PE, Rajagopalan B, et al

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Specifically, doses of 250 mg to 4,000 mg per day may help improve fasting blood sugar and HbA1c levels

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