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Progesterone receptor modulator-associated endometrial changes (PAEC) have been found to occur in 0.4% of patients using UPA while 41%78.8% of patients who developed PAEC appeared to be reversible upon discontinuing UPA ( Aromatase inhibitor is used to block the action of aromatase, an enzyme that is responsible for the conversion of androstenedione to estrogen, resulting in increased cell proliferation and fibrosis

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Therapeutic management Recommendations and suggestions R6.6 We recommend a multidisciplinary management approach for TT in specialized centers with expertise in pediatric and adolescent care, paying particular attention to the transition to ensure long term follow-up in adulthood (1, )

Oncogene 19 , 49474953 (2000)