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Interestingly, the expression of PNPLA2 and PNPLA3 oppose one another, with expression of PNPLA2 highest during conditions that promote TAG hydrolysis such as fasting, while the expression of PNPLA3 is highest during conditions that promote TAG synthesis such as feeding (62, 63)

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GIPR:GCGR co-agonism restores normal weight in obese rodents

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