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Nature 481 , 199203 (2011)

130,492,493 NASH is a liver disease primarily caused by fat accumulation, which can progress to liver fibrosis, cirrhosis, or even liver cancer

Specifically, a high-fat and high-sugar diet increased the -amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid to N-methyl-D-aspartic acid receptor current ratio in medium spiny neurons and prolonged spontaneous glutamate-mediated currents, increased DA release and slower DA reuptake in the striatum, and reduced MOR-mediated synaptic plasticity (73)

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This sensitization to TNF is due to the limitation of mGSH, as a result of the ethanol-induced mitochondrial cholesterol increase that alters membrane-order parameter and partially inactivates the mGSH carrier [41,74]

Sample Volume Limitations Many projects are constrained by scarce or precious material (e.g., small tissue biopsies, limited plasma volume, rare cell populations)