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Front Immunol (2017) 8:1719

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- Requires complete and accurate documentation (labs such as serum ferritin and transferrin saturation/TSAT, diagnosis codes, prior oral-iron trial or intolerance) to support medical necessity and reimbursement

While environmental triggers (e.g., viral load, infections) play a major role, genetic predisposition often determines who escalates to a full cytokine storm versus those who mount a controlled response