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Similarly, the increasing use of post-transplant high dose cyclophosphamide as a maneuver to reduce the risks for graft-versus-host disease (GVHD) [101] in patients undergoing allogeneic hematopoietic stem cell transplant, especially in peripheral blood stem cell and haploidentical transplants, is associated with high levels of cytokine release during the first 72 h following infusion of the hematopoietic stem cells