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In Arabidopsis, two genes each encode dual-targeted glutathione reductases (GR), and this is sufficient to explain the presence of GR activity in the chloroplasts, mitochondria, cytosol, and peroxisomes (Chew et al., K M value for NADPH below 10 M (Edwards et al., GR1 , encoding the cytosol/peroxisome enzymes, causes only moderate GSSG accumulation in leaf tissue, an observation explained by the existence of an auxiliary GSSG-reducing activity ensured by cytosolic NADPH-thioredoxin (TRX) systems (Marty et al., In contrast to GSSG reduction, the reactions that are most important in converting GSH to GSSG are less clear and, potentially, more complex

Agric Biol Chem 52:27532762 Ohtake Y, Watanabe K, Tezuka H, Ogata T, Yabuuchi S, Murata K, Kimura A (1989) Expression of glutathione synthetase gene of Escherichia coli B in Saccharomyces cerevisiae

Under physiological conditions, ROS maintain mucosal defense by regulating bacterial virulence, epithelial repair, and microbial communities

Because Plasmodium falciparum is an obligate intracellular parasite, it is challenging to evaluate cellular parasite enolase inhibition in isolation

You can customize your treatment with extra vitamins to help speed your recovery

Hippo pathway effectors YAP/TAZ as novel determinants of ferroptosis