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The most expensive complication of diabetes is nephropathy, which also increases the risk of diabetic foot ulcers and/or amputations

Targeting metabolic regulation, SGLT2 inhibitors like empagliflozin reduce glomerular hypertension through mechanisms independent of glucose-lowering, significantly lowering the UACR and improving podocyte injury, with their renoprotective effects validated in both animal models and clinical trials (Maruyama-Sakurai et al., 2024)

443 Researchers took more investigations beyond monotherapy

Phospholipids incorporating PUFAs contain unstable bis-allylic hydrogen atoms, making them highly susceptible to lipid peroxidation, which in turn drives the execution of ferroptosis [15]

Fu S, Li N, Zhou PC, Huang Y, Zhou RR, Fan XG

10.1006/exer.1997.0292 157 KerckhoveN.CollinA.CondeS.ChaleteixC.PezetD.BalayssacD