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IL-1 was identified as one of the cytokines related to osteoclastogenesis and with associated metastasis-promoting potential using a SCID mouse metastatic model of PCa [51]

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In-vitro studies using primary neuronal cells or immortalized neuronal cell lines (like PC12 or SH-SY5Y) have been used to examine the peptide's influence on neurite outgrowth, cell survival, and the expression of nerve growth factors

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