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Agents targeting glutamine metabolism, such as glutaminase or conversion of glutamate to alpha-ketoglutarate, have been developed (Zhang et al., 2017)

Therefore, for all participating HOPDs, we estimate a decrease in annual burden of 45,440 hours (14.2 hours per HOPD 3,200 HOPDs) at a savings of $2,501,926 (45,440 hours $55.06/hour)