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The diuretic ethacrynic acid (EA) is a potent and reversible inhibitor of GSTs 55

GSTs act on a wide variety of substrates, and each GST isoenzyme may function very differently from the others, wherein not all GSTs are involved in the detoxification of acaricides [10, 11]

These studies suggest that unique KP alterations may underlie specific clinical syndromes and highlight the potential of KP metabolites as diagnostic biomarkers and potential contributors to neuropathology