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131 ShaoY.ForsterS

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Climatic Change

Conclusions Artemisinin and its derivatives exhibit more potent antimalarial activity than iron chelators, likely stemming from their ability to accumulate in the parasites digestive vacuoles, interact more effectively with heme and iron, and thereby disrupt heme/iron homeostasis and utilization

For example, one study revealed that 7 days of therapy in rats led to a significant increase in serotonin synthesis in their brains

Our work confirms that dual suppression of exogenous uptake and endogenous synthesis is essential to potentiate carboplatin efficacy in NSCLC, a strategy particularly effective against Np63-driven LUSC