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These markers help quantify the metabolic benefits of tirzepatide beyond weight loss

Early response predicts long-term success

GCN5 related N-Acetyl transferases (GNATs) have derived their name from bearing similarity to yeast GCN5 (general control nonderepressible-5) enzymes, having GCN5, and its relative and some distantly related HATs like Hat1, Elp3, and Hpa2

Ann Intern Med 172(11):726-34 Liu J, Liao X, Qian S, Yuan J, Wang F, Liu Y et al (2020a) Community transmission of severe acute respiratory syndrome coronavirus 2, Shenzhen, China, 2020

The critical implication of these findings is that OA should be reconceptualized, in a significant subset of patients, as a systemic metabolic disorder rather than a purely localized joint disease