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In DDC mice, liver arachidonic acid (AA) concentration (by GC-MS) was increased, and RNA seq/qPCR showed suppression of mitochondrial STAT3 gene targets responsible for fatty acid oxidation and metabolism, all of which was reversed by GW4064

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Ostermann S, Csajka C, Buclin T, Leyvraz S, Lejeune F, Decosterd LA, et al

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

10.1016/j.meafoo.2024.100195 93 KeenumI.WindL.RayP.GuronG.ChenC.KnowltonK.et al (2022)

400,401 Coupled with its role in regulating cell proliferation, AKT signaling is involved in regulating glucose homeostasis and lipid metabolism