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The two most studied MTHFR single-nucleotide polymorphisms (SNPs) are C677T (rs1801133) and A1298C (rs1801131)

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TMEM165 and ATP2C1 are localized to the Golgi apparatus, where they regulate Mn uptake, supporting the activity of Mn-dependent glycosylation enzymes 5

Previous studies have shown a clear increase in RPP, specifically in continuous and fed-batch bioprocesses producing an antibody fragment (Fab) and the enzyme Candida rugosa Lipase 1 (Crl1) under GAP promoter ( P GAP ) regulation in hypoxic conditions when glucose was used as the carbon source

These data were combined using standardised mean differences (SMDs) and assessed using a random effects model