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Moreover, PGD 2 is metabolized by 11-ketoreductase to 9,11-PGF 2 [109]

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Chronic exposure to these drugs depletes presynaptic monoamine stores, impairs long-term neuronal signaling, and induces neurodegeneration ( 4.2 Oxidative stress and mitochondrial dysfunction The excessive release of monoamines promotes ROS formation through the auto-oxidation of dopamine and norepinephrine

Immunohistochemical findings The caspase-3 immunoexpression was negative in the spiral ganglia in control (Fig

Besides their physiological and clinical relevance, crystallization of bacterial GGTs also unveiled molecular aspects of autoprocessing and catalysis, emphasizing the role of conserved threonine that acts as a nucleophile

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