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Eur J Neurol 31:e16168 Ramirez CE, Okamoto LE, Arnold AC, Gamboa A, Diedrich A, Choi L, Raj SR, Robertson D, Biaggioni I, Shibao CA (2014) Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic failure

further notes that a restricted maintenance dose of just four injections per year is what is normally allowed, which can leave people physically and mentally unable to contribute to either family or society, and lead to permanent neurological damage

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