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25,211,492 In addition to targeting fragile X syndrome, mGluR5 inhibition has been shown to salvage many phenotypes, including learning and memory deficits, social deficits, repetitive behaviours, hyperactivity, and dendritic spine dysmorphogenesis, in 16p11.2 deletion mice, BTBR mice and Shank3- knockout mice

Noteworthy, mitochondrial FRT has not been detected in DRG neurons, a protein responsible to store free mitochondrial iron and with a very important role in antioxidant activity (Koeppen et al., 2007

however, no corresponding fall in AChR autoantibody titer was observed (125)

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