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Given the role of the endoplasmic reticulum in Ca2+ handling, altered intracellular Ca2+ levels may be indicative of its dysfunction [28]

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Quinlan P, Horvath A, Nordlund A, Wallin A, Svensson J

Front Mol Neurosci 10:451 Ziemens D, Oschmann F, Gerkau NJ, Rose CR (2019) Heterogeneity of activity-induced sodium transients between astrocytes of the mouse hippocampus and neocortex: mechanisms and consequences

The mTBI model in this study has been characterized to deliver repetitive, biomechanically relevant impacts, to induce CTE-like neuropathology and cognitive impairment ( TDP-43 is an important protein for stabilization of RNA processes such as transcription, mRNA stability and alternative splicing ( A key constituent of these NFTs is tau, a microtubule-associated protein involved in axon construction (Yin et al., 2010), but the tau-mediating involvement of ALC in mTBI has not been previously demonstrated