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This was patented by Novo Nordisk in 1996 and the first paper on it was published in 2000 (Knudsen, Nielsen, Huusfeldt)

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Colonisation of BCBM cells in the brain Once the cancer cells have exited the bloodstream, they begin the process of founding a metastatic colony

11 Education must encompass: the concept of central sensitivity as a continuum with complex biopsychosocial aggravating and ameliorating influences nociplastic pain not being indicative of peripheral tissue damage the importance of a multidisciplinary approach to management