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Importantly, low aldosterone levels in combination with low ADH exacerbate extracellular volume contraction, impair baroreceptor-mediated compensation, and perpetuate hypovolemia and orthostatic intolerance

Physiological closed-loop control (PCLC) systems: review of a modern frontier in automation

Epub 2016 Aug 22

These three pathophysiological pillars are intricately linked through a self-perpetuating redox-endocrine loop that amplifies metabolic and reproductive dysfunction

M1 macrophages rely on glycolysis to rapidly generate ATP and pro-inflammatory factors (e.g., IL-1, TNF-), while simultaneously producing large quantities of ROS