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The age-related decline in neuromodulators, neurotransmitters, and glutathione levels may account for the diminished cognitive benefits of caffeine and paraxanthine in older animals

In 0.4% of all subjects, endometrial hyperplasia was reported during or after UPA: simple hyperplasia (five cases) and simple atypical hyperplasia that resolved into benign secretory endometrium by the end of the treatment (one case)