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These data indicate that glutathione peroxidase-dependent control of intracellular reactive oxygen species accumulation is important not only for regulation of TH-cell proliferation, but also for modulation of differentiation into TH1, TH2 and TH17 cells.[26] Summary of the Role of Glutathione in Autoimmune Modulation Modulates TH-1 and TH-2 polarization which dampens AI tissue destruction Activates TH-3 regulatory T-cells which dampens AI tissue destruction Dampens TH-17 activity which dampens AI tissue destruction Enhances tissue and intestinal regeneration which enhances AI recovery Protects cell mitochondria which enhances AI recovery Clinical Strategies to Support Glutathione Levels and Glutathione Recycling If you look at the literature, there are several natural compounds that have been shown to help raise intracellular glutathione and support the glutathione recycling system: N-acetyl-cysteine Alpha lipoic acid L-glutamine Selenium Cordyceps Centella asiatica Silybum marianum Broccoli extract N-Acetyl-Cysteine (NAC) N-acetyl-cysteine is a metabolite of the sulfur-containing amino acid, cysteine