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Oxidative DNA damage is mainly caused by ROS, a complex process involving multiple reactions controlled by a combination of enthalpy, entropy, steric hindrance, and its constituent factors, as well as charge reactions and transport (7) ( Figure 1D )

J Neuroinflammation 22:39 Yang Y et al (2025) Tumor-associated macrophages remodel the suppressive tumor immune microenvironment and targeted therapy for immunotherapy

doi: 10.1074/jbc.M510644200 54 KimY

Your body uses it both directly as an antioxidant and as raw material for glutathione production

Although low serum B12 levels have been associated with increased bone turnover and fracture risk (9) , long-term B12 and folic acid supplementation did not improve bone mineral density (38) , or reduce osteoporotic fracture incidence in elderly individuals with elevated plasma homocysteine levels (39)