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In both groups, the locomotor activity onset (the time between activity onset and the start of the dark phase) was reduced, suggesting a better adaptation to light and dark phase changes

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6) Pro-Regenerative Crosstalk Human-centric reviews 9 detail how IGF-1 interacts with cytokines (e.g., IL-6) and niche signals to regulate repair dynamics, offering a systems-level explanation for why restoring IGF-1 signaling aligns with better recovery trajectories

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Euro-Mediterranean J Environ Integr 2025 105 10:39453954

A putative glycosylation site at Ser129/Thr130 was also associated with HDL ApoE (Zhu et al., 2019)