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In 2014, the US Food and Drug Administration (FDA) acknowledged a GRAS (Generally Recognised as Safe) notification for AOD 9604 as a food ingredient meaning the FDA raised no questions about the notifier's own safety conclusion

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Bone and musculoskeletal research: Some work has extended into bone repair and osteoporosis models, where AOD9604 has shown early signs of supporting bone remodeling, though this area is less developed than its fat metabolism and cartilage research

Researchers highlight this peptide for its capacity to influence NAD+ salvage and S-adenosylmethionine balancekey regulators of mitochondrial efficiency and adipocyte energy output