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However, despite elevated hepcidin and decreased bioavailability (% relative absorbed) with two doses per day [66], or daily iron dosing compared to alternate days [67], the total iron absorbed remains greater with a higher frequency of supplementation [notwithstanding any individual gastro-intestinal (GI) issues with greater individual doses]

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Similar results were also achieved by adding HCQ into the PPI-treated cancer cells in pH 7.4, which indicating that the increased protein overload stress in pH 6.5 was due to autophagy inhibition