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Many chronic injuries involve more than one site

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Long term studies have shown that with non-surgical treatment, symptoms can worsen in 15% of cases in 5 years and nearly 30% in 10 years

B12 is different than many other vitamin nutritional deficiencies in that it is only found in animal-based food products such as meat, dairy, and eggs which makes this a nutrient to be especially vigilant of for vegetarians and vegans

Given the absence of demonstrated abnormalities in fibril morphology or collagen synthesis, this mechanism may be the most plausible