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All of the variants tested resulted in either less active or inactive versions of the proteins

Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep

Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP

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They discovered that the protein kinase R-like endoplasmic reticulum kinase signaling was demanded for cardiac valve formation via CPT2-dependent FAO and EndoMT