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Metabolic biomarkers are important tools for therapeutic monitoring and follow-up of disease progression (17,30)

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Although initially activated to buffer metabolic stress, the PINK1-Parkin pathway becomes suppressed under chronic overload, such as prolonged palmitate exposure, resulting in dysfunctional mitochondria, heightened oxidative stress, and activation of the NLRP3 inflammasome

Cell 173 , 386399 (2018)

Repurpose of the antibiotic NFT as activator of Nrf2 could thus be a promising strategy for a transient and targeted activation of the endogenous antioxidant machinery

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