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doi: 10.1016/j.aquaculture.2020.736261 384 ZhouL.WeiJ.LinK.GanL.WangJ.SunJ.et al

J Thorac Cardiovasc Surg 158(3):911-919.e6, 2019

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Understanding CJC-1295: DAC vs No DAC CJC-1295 without DAC (Mod GRF 1-29) Half-life: 30 minutes to 1 hour Dosing: 1-3 times daily Best for: Mimicking natural pulsatile GH release Recommended for Ipamorelin combo: YES CJC-1295 with DAC Half-life: ~8 days Dosing: Once or twice weekly Pattern: Sustained GH elevation (plateau, not pulses) Recommended for Ipamorelin combo: Not ideal For the Ipamorelin combination, CJC-1295 without DAC is strongly preferred because it creates natural GH pulses rather than constant elevation, which can lead to receptor desensitization