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EV, HC, EB and MO wrote the manuscript

& Peraza, R

Through a deeper knowledge of the biological function and regulatory mechanism of HO-1, it can provide groundbreaking ideas and strategies for the therapy of diabetic nephropathy

On the other hand, if SAM is low, then the inhibition of MTHFR is withdrawn and 5mTHF rises inhibiting GNMT more, so fewer methyl groups go on the GNMT pathway, saving them for the other MT pathways